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Partners and Solutions / Nanoparticle Size Analyser

  Nanoparticle Size Analyser

Analytik delivers ultra high resolution particle size analysers based on the powerful technique of Differential Centrifugal Sedimentation (DCS) to the UK and Ireland from CPS Instruments Europe.

We will be happy to work together with you on a solution with the full support of the CPS Instruments Europe team. Visit our contact page, request a quote, or call us on +44 (0)870 991 4044.

 

CPS Disc Centrifuge UHR    

The CPS DC24000 UHR is an effective analytical tool for ultra high resolution, high accuracy measurement of particle size distribution. Highly poly-dispersed particles can be measured in the size range of ~2.0nm to ~75 microns, at 2 to 10 times better resolution than any other particle sizing instrument, regardless of measurement technique.

Utilising Differential Centrifugal Sedimentation (DCS), the CPS Disc Centrifuge UHR offers the unique ability to resolve very close multimodal particle distributions and to distinguish extremely small shifts in particle size. Rather than using a predictive algorithm, the instrument physically separates the nanoparticles and then measures them as they pass a light source detector - providing full characterisation in real time.

Do you know the real size of your nanoparticles? Watch an introduction to the CPS Disc Centrifuge UHR below.

 

Key Features:

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  • Ultra high resolution with clean separation of narrow peaks that differ in size by as little as 2%
  • Able to detect and measure very small and subtle changes / differences in particle size
  • Able to measure / monitor nanoparticle coating thickness
  • In-built PC: the display shows the actual disc speed, internal temperature and it will show a user if the system is unbalanced
  • Dynamic Balancing Module ensures instrument longevity
  • Very high sensitivity; minimum detection limit below 10-8 gram active sample for narrow peaks
  • Highly reproducible results
  • Dynamic range capability >1000 for measurement of broad and multimodal distributions
  • Measurement of particles of virtually any density
  • Wide range of data presentation options, including multiple distribution overlays

Applications:

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Pharmaceutical

• Gold and silver nano-particles (coated and/or uncoated)
• Virus particles/virus-like particles
• Cells (culture) and cell fragments
• Protein clusters
• Liposomes
• Particles in diagnostic tests
• Micro-encapsulated drugs


Chemical

Polymer latexes and emulsions
Fillers (CaCO3, clay, barites, etc.)
SiO2 dispersions
Abrasives (of all types)
Impact modifier particles
Oil emulsions

• Carbon nanotubes
• Quantum dots
• Metals and metal oxides


Printing and painting

• Pigments - water and oil based
• Micro-fibre paint viscosity modifiers
• Printer/copier toner powders
• Inkjet inks
• Carbon black
• Magnetic iron oxide


Semiconductor

• Micro-abrasives
• CMP compounds for integrated circuits


Others

• Micro-spheres
• Agglomeration patterns
• Starch/flour particles

 

Request a quote for the CPS Disc Centrifuge UHR or call on UK: +44 (0)870 991 4044 / IE: +353 (0)151 43753.

 

CPS Disc Centrifuge UHR datasheet

 

Product Recommendations:

“We purchased the CPS Disc Centrifuge from Analytik in 2008 expanding our range of particle and material characterisation instrumentation. The ability of the instrument to detect and measure small changes in particle size distribution enables us to determine coating thickness on particles and multi-mode particle distributions. It’s easy to use so we now have many trained users. We get great support from Analytik for servicing, extra training and answering any queries we might have about samples.”

Alison Crossley, Manager, Oxford Materials Characterisation Service

We have been using the CPS Disc Centrifuge routinely for several years to analyze aqueous dispersions of gold nanoparticles in the 3 to 25 nm size range. It copes very well with the presence of multimodal size distributions, which usually lead to the appearance of well separated peaks. For monodisperse samples the method uniquely provides the opportunity to monitor changes in the thickness of the organic ligand shell down to the length of a single chemical bond (see Krpetic et al. ACS Nano 2013)”

Mathias Brust, Professor of Chemistry, University of Liverpool

We are using the CPS Disc Centrifuge on daily bases to analyze the aqueous colloidal dispersions of biocides in less than 100 to 500 nm size range. The instrument operation is very easy and results are reproducible with comprehensive.”

Farnoosh Kianfar, Senior Formulation Scientist, Lonza

Here at Intertek Wilton, we have been using the CPS Disc Centrifuge to provide a particle sizing service to a wide range of industries including Pharmaceutical and Materials based businesses. This instrument should be an essential part of any laboratory where particle sizing is performed as it enables accurate measurement of particles where other techniques (e.g., laser diffraction and PCS) run into difficulties due to size and concentration, I'd also recommend Analytik because of their unceasing support whenever we require advice on running materials we have never encountered before. ”

Jonathan Whitehead, Senior Experimental Scientist, Intertek Testing Services

Before we purchased our CPS we routinely analysed samples by DLS. While sample analysis is not as straight forward as with our DLS instrument (it requires you to build a sucrose gradient inside the disc prior to analysis, where with our DLS instrument you just insert the cuvette and press go) the resolution far surpasses what we were used to, and is well worth the little extra effort. We routinely analyse samples looking to detect the level at which influenza virus particles may be present. ”

Kevin Murphy, Technical Specialist, Novartis Vaccines and Diagnostics

 

More Downloads:

Whitepapers

An introduction to particle size characterisation by Differential Centrifugal Sedimentation (DCS)

Technical / Application Notes

Comparison of Laser Diffraction and DCS

Quantitative analysis of nanoparticles using DCS

Particle sizing; Are you getting the full picture?

Carbon nanotubes: Analysis of CNTs using the CPS Disc Centrifuge ‘UHR’

Latex and nanocomposite particle sizing: Advantages offered by the CPS Disc Centrifuge

Bio nanoparticle sizing: Analysing growth in real time with the CPS Disc Centrifuge

Characterising coating thickness for gold and silver nano-scale drug delivery

Adenovirus particles: Monitoring the production and purification process

Filter testing: Determination of pore size distribution using the CPS Disc Centrifuge

News Releases

Analytik report on use of the CPS Disc Centrifuge for measurement of nanoparticles by the NPL

Analytik reports on the use of the CPS Disc Centrifuge system at the National Physical Laboratory

Analytik reports on the University of Sheffield using the CPS Disc Centrifuge for particle characterisation

Analytik report on work at the University of Loughborough applying the CPS nanoparticle size analyser

University of Leeds choose CPS DC24000 to enhance particle characterisation capability

UMPF selects CPS DC24000 to aid fluid processing research at the nanoscale

Analytik launches NEW Ultra High Resolution Disc Centrifuge

University of Liverpool choose CPS DC24000 to monitor coating thickness of drug delivery vehicles

University of Warwick selects CPS DC24000 for polymer colloid characterisation

University of Birmingham uses CPS DC24000 for bio nanoparticle analysis

University of Sheffield selects CPS DC24000 to analyse latexes and colloidal nanocomposite particles

Intertek MSG choose CPS DC24000 for nanoparticle characterisation

Begbroke Nano uses CPS DC24000 for nanoparticle characterisation

Useful Links:

 

Particle Characterisation Interest Group
A group within the Analytical Division of the Royal Society of Chemistry

 

Characterisation of Nanoparticles in Solution

The National Physical Laboratory (NPL) offers extensive expertise in handling different type of nanoparticles, together with a wide range of powerful tools for high resolution particle characterisation

 

Begbrokenano
UK Micro Nano Technology (MNT) Centre of Excellence - aims to provide companies with unrivalled facilities for materials characterisation

Nanocentral
Alliance of leading companies created to unlock the commercial and societal potential of nanomaterials

 

 

Visit CPS Instruments Europe website

 

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-CPS Disc Centrifuge UHR Nanoparticle Analyser

 

Ultra High Resolution Capability – detect, measure & resolve peaks which differ in size by as little as 2%-

Ultra High Resolution Capability

 

High sensitivity - detect & measure extremely small and subtle changes in size distributions e.g. small additional peaks-

High Sensitivity


Accurate, Reliable & Reproducible Results – traceability & calibration to NIST particle size
-Accurate, Reliable and Reproducible

 

-    Results comparable with SEM microscopy analysis

Results Comparable to SEM Analysis-

 

A mixture of single adenovirus particles and multiple aggregations of the same adenovirus particles can be easily resolved

Resolve Aggregates and Agglomerates-

 

Characterise coating of nanoparticles – ability to measure / monitor coating thickness

Measure Particle Coating Thickness-

 

Resolution comparison with Laser Diffraction and Dynamic Light Scattering-

Resolution comparison-

 

Disc in rotation furing analysis. note the seperated bands of different sized particles as they approach detector.

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